In view of the pivotal role of adhesion and chemokine receptors in tissue-specific lymphoma dissemination, dysregulated 'homing' of lymphoma cells carrying oncogenic MYD88 and/or CD79 mutations could present an alternative mechanism underlying the observed site-specific differences in prevalence of these mutations in DLBCL.
In contrast, integrins were found to play a pivotal role in early adhesion: their activation significantly enhanced C2C12 myoblast spreading on soft films, where they were otherwise round.
Furthermore, the elevation of extracellular D-glucose did not affect the expression of CD11b/CD18 integrins in leukocytes, which are pivotal leukocyte molecules for adhesion and migration [35].
Cadherins play pivotal roles in controlling adhesion and epithelial-to-mesenchymal transition (EMT) (Oda and Tsukita 1999).
Microvascular permeability and leukocyte adhesion are pivotal mechanisms in sepsis pathophysiology contributing to the development of shock and mortality.
This receptor is believed to play a pivotal role in growth, adhesion, survival, angiogenesis, and invasion of tumor cells [ 2, 6, 7].
von Willebrand factor (VWF), a large circulating glycoprotein mainly derived from vascular endothelium, also plays a pivotal role in platelet adhesion and aggregation at sites of high shear rates such as in arteries with stenotic or ruptured atherosclerotic plaque lesions.
Certain lines of evidence have indicated that ICAM‐1 and EPCR may play a pivotal role in the adhesion of iRBC in cerebral vessels and, therefore, in the pathology of CM (Turner et al., 1994; 2013; Newbold et al., 1997; Moxon et al., 2013).
One of the PKG-I actions is the phosphorylation, mainly at serine 239, of the vasodilatory-stimulated phosphoprotein (VASP): VASP is a thin filament-actin binding cytoskeletal protein playing a pivotal role in cell adhesion, motility, and migration and by binding to actin filaments and stress fibers in cell contraction [ 19– 23].
In fact, it is now considered that abnormal red blood cell (RBC) adhesiveness in SCA through activation, sustained or increased expression of adhesion molecules is pivotal in the genesis of vaso occlusive crisis, the hallmark of SCA (Hebbel et al., 1980).
