When the Forth Bridge opened in Scotland in 1890, its English architects didn't know their pioneering structure would come to stand as a 20th century retelling of the myth of Sisyphus.
To develop vaccines that protect against antigenically variable pathogens, pioneering structure-based work demonstrated that multiple strain-specific epitopes could be engineered onto a single immunogen.
Gen Xers pioneered the idea of structured, personal retirement planning by integrating the 401k into the core of their retirement plans.
The GENIA task is a publicly accepted task within the BioNLP communities and it is a leading pioneer in the area of structured event extraction.
Frederic Middlebrook Richards (August 19 , 1925 January 11 , 2009), commonly referred to as Fred Richards, was an American biochemist and biophysicist known for solving the pioneering crystal structure of the ribonuclease S enzyme in 1967 and for defining the concept of solvent-accessible surface.
X-ray structure analysis has revealed high similarity within the active site of the two enzyme types, with only slight differences, most prominently a bulky amino acid that limits substrate access to the active site, which was first identified in the pioneering crystal structure of the catechol oxidase from Ipomoea batatas.
Yu-Tao Loo (1906 1985) (Fig. 1) was one of the Chinese neuropsychologists who acted as a pioneer of structure and functions studies of human cerebral cortex (Qian 2013) in China.
In this aspect, pioneer systematic structure-activity relationship studies have already identified compounds able to abolish GPR91 function both in human and rats [ 13].
There was pioneering in the structure of the show as well, and in its scripts.
The proposed PC based nanofluidic structure pioneering a novel style for future optofluidic design.
There are some pioneering works in structure-oriented study on multiple equilibria of networks [ 3, 9- 17], which have recently been surveyed in [ 5].
