Sentence examples for pioneering function from inspiring English sources
We find no evidence of a pioneering function of PU.1 during late GM-lineage differentiation.
Besides the pioneering function on the AR pathway, FOXA1 depletion elicited extensive redistribution of AR-binding sites (Sahu et al. 2011a, b; Wang et al. 2011).
In addition to the pioneering function of FOXA1 for interaction with condensed chromatin, ER also requires a host of cofactors in order to regulate gene transcription of its target genes.
The pioneering function of Anglo-Saxon countries is plausible because the necessity of making transparent decisions in their health-care systems, which are financed by the national treasury, is considerably greater than in systems which are based on private and social insurance systems.
A long this line of argumentation, such an epigenetic chromatin remodeling role, especially for NFAT2, in transcriptional regulation has been suggested: Because NFAT2 is strongly upregulated in Th0 cells, it has been speculated that the NFAT-mediated pioneering function provides the T cell with plasticity to differentiate in multiple directions, depending on the cytokine environment [ 81].
Instead, we delineate a set of enhancers that gain accessibility in a CEBPA-dependent manner, suggesting a pioneering function of CEBPA.
Finally, to decipher the specific weight of other pioneering functions that might compensate functionally the inactivation of FOXA1 is critical for future therapies.
The mechanisms responsible for de novo gain of chromatin accessibility, known as "pioneer" function, remain poorly defined.
Many of these early-born cells serve a pioneer function, which explains the stereotyped pattern of tracts and commissures seen in the ventral neuropil throughout the insects (Thomas et al., 1984).
But instead it appears that other pioneering factors function to first set up these enhancer repertoires.
Charles Kean in England and George II, duke of Saxe-Meiningen, in Germany were among those who, by coordinating spectacular visuals and ensemble acting, pioneered the function of the régisseur (known as the producer in England and the director in America).
