Sentence examples for pioneering factor from inspiring English sources
The phrase "pioneering factor" is correct and usable in written English.
It can be used to describe an element or aspect that plays a significant role in leading or initiating change or development in a particular field or context.
Example: "The pioneering factor in the development of renewable energy technologies has been the increasing demand for sustainable solutions."
Alternatives: "leading element" or "trailblazing component".
This analysis suggests that FOXM1 might act as a pioneering factor for ERα binding in the presence of TAM and E2.
Carroll et al. [ 25], for example, using ChIP-on-chip demonstrated that the Forkhead factor FoxA1 plays an important role as pioneering factor for ERα binding to chromatin in BC cells, while Cicatiello et al. [ 26] identified novel gene regulation cascades mediating estrogen actions in hormone-responsive BC cells.
The other may reflect the differences of their activation domains: although IRF1's activation domain can potently activate transcription, our data argue that only the activation domain of IRF2 can act as a pioneering factor to prepare chromatin for rapid transcription induction in response to stimulation.
More work is needed to tease out the dynamics of RelA and PU.1 involvement in the binding of IRF5, but it is highly likely that PU.1 binds first because it functions as a pioneering factor in macrophages (Garber et al., 2012; Ghisletti et al., 2010; Heinz et al., 2010), followed by the binding of RelA at inflammatory gene loci and subsequently docking of IRF5.
As an example of a high regulatory load gene, the genomic locus of SPI1 – the well-known pioneering factor and key regulator of macrophage differentiation – with two large clusters of multiple enhancers, is depicted in Fig. 4c.
Both receptors can bind nucleosomal DNA and have accordingly been described as pioneering factors.
But instead it appears that other pioneering factors function to first set up these enhancer repertoires.
Such regulatory region switching is commonly observed during cellular differentiation and development (Nord et al., 2013) and is often driven by pioneering factors like FoxA transcription factors (reviewed in Zaret and Carroll, 2011).
In turn, the liver pioneer factor FOXA2 is necessary for TET1 binding to the P1 locus.
Cistrome and chromatin analyses revealed that HNF4G is a pioneer factor that generates and maintains enhancer landscape at gastrointestinal-lineage genes, independent of androgen-receptor signaling.
We implicate the pioneer factor FOXA1 as a driver of enhancer activation in this system, a mechanism that renders PDA cells more invasive and less anchorage-dependent for growth in vitro, as well as more metastatic in vivo.
