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Apcher, S. et al. Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation.
Fundamental questions remain concerning the mechanism and biological significance of the pioneer round of translation.
This implies that a pioneer round of translation and establishment of polysomes can occur already in the perinuclear region.
Such mRNA could potentially be degraded during the pioneer round of translation thus explaining the absence of N-Bak protein.
Thus, the N-Bak mRNA could be degraded during the pioneer round of translation, explaining the absence of the protein.
CTIF is involved in the first, pioneer round of translation, taking place directly after nuclear export of mRNA [ 25, 26].
Similar(30)
In 1922 they began preparations for a pioneer round-the-world flight in a Vickers pusher-amphibian aircraft, but Ross was killed, together with Bennett, while testing the aircraft at Brooklands, and Keith abandoned the project.
hEST1A/B (SMG5/6) are structurally closely related bifunctional metazoan proteins with roles in telomere maintenance and in the nonsense-mediated mRNA decay (NMD) pathway that degrades mRNAs containing premature stop codons during quality-control pioneer rounds of translation in the nucleus.
Sutton uses many real-life examples, like Tetley's pioneering round teabags, to show readers how his suggestions can work.
I love this: John Lennon - before he was a Beatle, before the floppy bowl cut, before he pioneered round glasses - so inspired by Presley that it permeated everything he did, said and wore.
The EJC remains stably associated with spliced mRNAs after their export to the cytoplasm, until it is removed by the ribosome during the "pioneering" round of translation [2].
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