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The Belgian painter James Ensor abandoned Impressionism at the end of the 1880s for a bitter and fantastic style that was a pioneer example of extreme expressive alienation.
A pioneer example is the BioBricks project which focuses on the design and construction of genetic circuits and on their expression in host cells to produce a useful behavior or compound.
This work can therefore be considered a pioneer example of the application of metagenomics to food microbiota, and we hope it will pave the way to extend the strategy to other fermented foods, towards a deeper understanding of bacterial metabolic functions which could be beneficial to human health or of technological interest.
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Although they were preceded in print by other pioneer examples, like those of Torelli (from 1698), Tomaso Albinoni (from 1700), and even Vivaldi (from 1712), some of them may have been among the "several concertos" by Corelli that Muffat had already heard in Rome by 1682.
Pioneer examples in this work include large-scale efforts from the Encyclopedia of DNA Elements (ENCODE) consortium [ 2] seeking to catalog regulatory elements in the human genome, and the Pleiades Promoter Project [ 3] identifying brain-specific regulatory elements using humanized mouse models [ 4, 5].
Though its output was small, its claim as a pioneering example of New Wave is valid.
The recent agreement in principle between the European Union and Canada is a pioneering example.
"The 400 Blows" was a pioneering example of an autobiographical film.
A pioneering example is the Lingotto Factory Conversion, Renzo Piano's decade-long transformation of Fiat's defunct plant.
"Sparkle and Spin" is a pioneering example of a children's book subgenre one might call designed picture books.
A pioneering example of meta-theatre, it has often seemed to be in search of a meta-audience.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com