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Given the very large HCMV proteome, extensive collections of HCMV deletion mutants are instrumental for identifying unrecognized interfering factors and pinpointing responsible HCMV genes.
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However, due to the large number of mosquito genes encoding detoxification enzymes [ 15- 17] pinpointing those responsible for resistance remains challenging [ 18].
The hope for this so-called genome-wide association study is that, when the genes of people with diseases like cancer and multiple sclerosis are compared with the genes of those in good health, computer analysis will pinpoint genes responsible for the illnesses.
To determine whether the presence of PGG during the early stage G0/1 progression was necessary for G1 arrest and to pinpoint the responsible molecular events, we delayed the starting time for PGG exposure in reference to serum stimulation.
Several studies have attempted to pinpoint factors responsible for conferring resistance [ 14- 16], but confounding factors, such as, tissue types, virus strains and ages of birds have made it difficult to find a consensus.
"Pinpointing the genes responsible for natural resistance to cholera will help the development of better vaccines," The Times reported.
The scientists hope that by pinpointing the genes responsible and identifying their function, the research will point the way to new treatments.
He did this by inbreeding mice until they were so genetically similar that it was possible to transplant organs between them – demonstrating that compatibility was genetically determined and pinpointing the genes responsible.
Pinpointing the genes responsible for natural resistance to cholera will help the development of better vaccines, said Dr. Regina C. LaRocque, an infectious disease expert at the Massachusetts General Hospital and an author of the study, published Wednesday in the journal Science Translational Medicine.
Pharmaceutical companies those much reviled things–now have the tools to map the genomes of new viruses and bacteria in hours and days, pinpointing the genes responsible for illness and death and priming antibiotics and vaccines to target the enemy.
A comparative approach will be particularly important for pinpointing the regions responsible for pattern variation in Heliconius.
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