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In addition to pinpointing candidate areas for future protection efforts, the results highlight several challenges to conservation in the region.
Transcriptome analysis can also contribute valuable information to the discovery of new biomarkers, being capable of identifying changes in gene expression levels between different study groups, thus pinpointing candidate genes that may be up- or downregulated in a disease situation.
Given that R-genes are frequently located in clusters across genomes, with numerous copies of homologous sequences, Musa BACs containing RGAs were identified, as a resource for pinpointing candidate genes and for contributing to our understanding of R gene evolution.
Our study reveals the evolutionary trajectory of stress responsive gene families in the green algal lineage, and because lipid production is sharply induced by stress [ 2], our results could help pinpointing candidate genes for further study on lipid metabolism.
With the goal of validating the microarray data and further pinpointing candidate genes that might be involved in bundle formation, we selected 3 genes including NT-3, cloned these by reverse transcription polymerase chain reaction (RT-PCR), and carried out in situ hybridization.
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The Vra1 candidate region of 9 Mb contains 59 genes in the rat of which 45 are protein coding and 14 pseudo genes, which is too large a number to pinpoint candidate genes.
Sequence data of 263 animals enabled us to pinpoint candidate causative mutations for two haplotypes with a homozygosity deficit.
Subsequently, genomic variants are used in database searches to pinpoint candidate genes whose function may be related to the observed phenotype.
Thus, developing computational models that identify these essential properties and pinpoint candidate AMPs have gained interest (Fjell et al., 2012; Maccari et al., 2013).
Chicken chromosome paints revealed that white-throated sparrow chromosome 2 was analogous to chicken chromosome 3 [ 62], now allowing us to pinpoint candidate genes associated with phenotypic differences.
Compared to methods based only on recurrent copy number alterations, MutComFocal is able to pinpoint candidate driver genes in regions encompassing large genomic alterations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com