In the present study we utilized three widely used prostate carcinoma cell lines, namely, PC3 and DU145 castration-resistant cells, and LNCaP androgen-dependent cells, and utilized transgenic and immunological strategy to pinpoint the function of Mitostatin in these cells.
To pinpoint the function of each stem-loop beyond base pairing, we examined their contributions to stability and Hfq interaction.
However, to date, it has been difficult to pinpoint the function of RNA granules and other bodies (Decker and Parker, 2012; O'Connell et al., 2012).
Knowledge of the proximodistal expression pattern may therefore indirectly facilitate pinpointing the function of Adhesion GPCR orphans.
A better understanding of the role of Mnn4p is expected to help to pinpoint the molecular functions of FKTN and FKRP with respect to the post-phosphoryl modification on α-dystroglycan.
Though further investigation will be required to pinpoint the exact function of Rv3802, examination of the mycolic acid synthetic pathway suggests a role as a Pks associated thioesterase or as a mycolyltransferase.
This new tool would allow us to pinpoint the exact function of Rn protein and provide a handle for uncovering the molecular mechanism of ORN diversification.
Altogether these observations pinpoint the important role of eIF3f in S6K1 activation and function in the control of muscle mass and size.
Mechanistic studies of the genes identified in the present study, though beyond the scope of the present report, are ongoing by our combined laboratories that aim to pinpoint the precise functions and mechanisms of the identified transcripts for lens epithelial cell mitochondrial regulation, lens cell survival, lens cell differentiation, lens development and the maintenance of lens transparency.
However, our understanding of the molecular genetics of spore/pollen development remains poor due to the complexity of the developmental process and problems in pinpointing the actual function of the genes involved.
