Differences between D4 and D0 pinpoint selective processes because nonsynonymous changes are much more deeply imprinted by natural selection than synonymous ones.
To pinpoint positive selection within Lanceocercata we obtained partial cDNA sequences of seven core glycolytic enzymes, together with the enzymes immediately before and after the pathway, across a phylogeny of 29 Lanceocercata species.
Furthermore, the findings of strong negative Tajima's D values in the absence of other features of positive selection, pinpoint HBD as a target of purifying selection like previously reported for innate-immunity genes under strong functional constraints (Barreiro et al. 2009; Mukherjee et al. 2009; Wlasiuk and Nachman 2010).
Simulations have shown that SweeD's ability to pinpoint the target of selection is compromised if both selection and demographic perturbations have occurred (Pavlidis et al. 2010a) with the predicted target being tens of kilobases away from the actual location of selection.
Our results show some key aspects for the choice of the method and pinpoint pitfalls in the selection of a receptor template.
The above findings, however, do not unambiguously pinpoint the causality, as selection into various groups may provide alternative explanation, so more research of the effects of UISAs is needed.
To pinpoint loci under positive selection, we calculated the XP-EHH statistic between Holstein and Hanwoo population groups.
We employed model selection to pinpoint particular environmental agents most strongly associated with observed divergence in gonopodial features between fragmentation regimes.
Rapid evolution is a characteristic of genomes involved in antagonistic virus-host interactions 28; therefore, identifying sites evolving under positive selection can pinpoint mutations with fitness consequences.
By extrapolation, the observed positive selection may pinpoint the genes that are directly involved in male reproduction, which would be an important step towards understanding the molecular basis of gamete interaction during reproduction in Ectocarpus.
Thus, identifying proteostasis modifiers from among natural variants shaped by selection may pinpoint the potential genes and networks that are naturally plastic [ 23] and thus can be pharmacologically modulated without negative effects on the organism.
