To pinpoint processes that were particularly dependent on the MVB pathway during starvation, we identified 135 proteins that showed the most significant differences in changes of protein abundance between WT cells and vps4∆ mutants.
This assessment was done in three steps: pinpoint which process step had the highest influence on the risk, identify which management option(s) could be the most effective to control and/or reduce the risk, and finally evaluate quantitatively the influence of changing process setting(s) on the risk.
Although DCM can provide evidence for the presence of feedback processes, its temporal resolution is not sufficient to pinpoint these processes in time.
One drawback of this measure, however, is that it does not pinpoint which processes imposed the reported cognitive load.
Differences between D4 and D0 pinpoint selective processes because nonsynonymous changes are much more deeply imprinted by natural selection than synonymous ones.
The integration of methods and data sources proposed here yields a sensitive tool, able to pinpoint new processes with a role in cancer, dissect modulation of their activity and detect the varying assignments of genes to functional modules over the course of a disease.
Combination of these methods results in a sensitive tool, able to pinpoint the processes that change their intensity and to detect varying assignments of genes to functional modules, as the interplay between the developing tumor and the host organism creates new challenges and tasks for both.
The fact that plastic in the ocean attracts and accumulates chemicals is well established, but the Lausanne lab will attempt to pinpoint how this process happens over time, and what level of chemical toxicity should be expected in the world's oceans over time.
In particular, the GCC-PHAT manipulation not only highlights the less dominant source but also allows one to pinpoint, and then process in the most appropriate way, potential "ghosts" which may be generated by constructive interferences in the acoustic map domain.
Due to the pleiotropic phenotype of dnd1 it is far from straight forward to pinpoint the exact process which blocks the apoplastic ROS signal initiated by O3 treatment.
