By comparing the two tick symbiont genomes with several genomes of the pathogenic species C. burnetii and other Legionellales, we also pinpoint functions that might have been lost in the process of becoming an intracellular mutualist of ticks.
In the present study we utilized three widely used prostate carcinoma cell lines, namely, PC3 and DU145 castration-resistant cells, and LNCaP androgen-dependent cells, and utilized transgenic and immunological strategy to pinpoint the function of Mitostatin in these cells.
To pinpoint the function of each stem-loop beyond base pairing, we examined their contributions to stability and Hfq interaction.
However, to date, it has been difficult to pinpoint the function of RNA granules and other bodies (Decker and Parker, 2012; O'Connell et al., 2012).
Knowledge of the proximodistal expression pattern may therefore indirectly facilitate pinpointing the function of Adhesion GPCR orphans.
Thus, the KAD rat pinpoints a function of APC in the regulation of inflamed colonic states, separate from the tumor-suppressing functions encoded proximally to the C-terminus.
We have investigated the role of the unique Polκ gap and N-clasp structural features in the fidelity of minor groove lesion processing with extensive molecular modeling and molecular dynamics simulations to pinpoint their functioning in lesion bypass.
In summary, CD38 is a widely expressed enzyme and receptor, involved in various cellular functions, making it difficult to pinpoint one particular function that would most critically impact CLL pathobiology.
Other tests, too, may be more successful in pinpointing specific functions associated with these different prefrontal regions (Stuss, 2006).
These studies have pinpointed various functions of Smad7 in a large array of biological processes including early embryonic development, fibrosis of many organs, skin cell differentiation, regulation of immune response and inflammation, tumorigenesis, and metabolic control (Table 1).
