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Alternatively, E144R might affect the conformation or location of ribosomal proteins Rps28 and Rps14, also located in the exit channel and in contact with the Rps5 β-hairpin (Hussain et al., 2014), or of domain 1 of eIF2α, which interacts with other regions of Rps5 as well as Met-tRNAi in the PIN complex.
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DOI: http://dx.doi.org/10.7554/eLife.10147.015 How does the history of the GKPID-Pins complex relate to the evolution of spindle orientation?
In Drosophila, that role is fulfilled by Inscuteable (Insc), which functions by coupling the LGN (Pins) complex with the Par complex [ 37,4,38] to direct LGN apical localization and determine orientation of the spindle.
Taken together, these findings suggest that spindle orientation mediated by the GKPID-Pins complex in response to external cues replaced a more ancient mode of spindle orientation along the stem lineage leading to animals.
In this Letter, we investigate the problem of pinning a complex dynamical network to the solution of an uncoupled system.
The Showcase Leisure Park contains a 12-screen cinema, a 10-pin bowling complex and numerous restaurants.
This centrosome-attracting activity likely involves the recently identified Gαi-Pins-Mud complex that localizes at the anterior cortex and regulates centrosome-cortex interaction [29], [30], [31], [32].
The MCL algorithm has been shown to be the best amongst several approaches available for clustering PINs into complexes [ 29].
Nowadays 3 Nf3, which avoids having to deal with the complex pin that results from 3... Bb4, has stolen the show.
The yeast PIN excluding protein complex data was obtained from http://www.umich.edu/~zhanglab/download.htm[ 32].
There exist some fundamental and yet challenging problems in pinning control of complex networks: (1) What types of pinning schemes may be chosen for a given complex network to realize synchronization?
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