In a one-year project funded by United States Department of Health and Human Services, the Vaccine Formulation Laboratory transferred the process know-how and associated equipment for the pilot-scale manufacturing of an oil-in-water adjuvant to Bio Farma, Indonesia's state-owned vaccine manufacturer, for subsequent formulation with H5N1 pandemic influenza vaccines.
The current clinical studies (Table1) have shown that the pilot-scale manufacturing process of cell-based formalin-inactivated EV71 vaccine candidates has been successfully developed, optimized, characterized, and quantified.
Informatics infrastructure plays a crucial role in supporting different decision making activities related to pharmaceutical product development, pilot plant and commercial scale manufacturing by streamlining information gathering, data integration, model development and managing all these for easy and timely access and reuse.
In addition, simple process of preparation makes them more suitable for industrial scale manufacturing.
Meanwhile, it can be applied at the pilot scale as a manufacturing process for edible and medicinal plants.
Thus, technology transfer from laboratory scale to pilot scale to full manufacturing was successfully completed.
The validated model was used for the estimation of drying times of six different pharmaceutical compounds at the pilot and manufacturing scale over a range of drying conditions – pressure 15 200 mbar, temperature 45 70 °C, solvents: acetone, water, methanol, n-propanol, and isopropyl acetate.
The plastic is being made on a pilot scale, and Novomer declines to give details of its commercial-scale manufacturing plans.
To determine BSE prion inactivation during the manufacturing process of MBMs, industrial processes were replicated on a pilot scale by using BSE-infected brains, and the infectivity of processed materials in each step was investigated in detail [ 9].
experiments were carried out in a pilot scale upflow reactor.
Measurements in a pilot scale stirred tank gave similar results.
