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The quality of the design of the loading facilities and of the handling procedures plays a key role in determining the effects of the farm on pig response to preslaughter stress, as it may contribute to improve to reduce the load time, the staff workload and stress in pigs.
Our main focus regarding the meta-analysis was the set of genes involved in the pig general immune response and then in the pig response to PRRSV infection.
Thus, for the pig global immune response, we used 779 chips that corresponded to 29 datasets; and for the pig response to PRRSV infection, we used 279 chips obtained from 6 datasets (Additional file 1: Table S1).
Microarrays have recently been employed successfully to identify the molecular pathways involved in the pig response to a number of different microbial pathogens and to identify disease resistance candidate genes [ 15- 18].
We used 779 chips corresponding to 29 datasets for the pig global immune response and 279 chips obtained from 6 datasets for the pig response to PRRSV infection, respectively.
All experiments data on pig response to diverse pathogens, time period of observation, challenge system (in vivo/ in vitro), pig tissues/cells and microarray platforms (Additional file 1: Table S1), were considered for this study.
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The aim of this study was to investigate the influences of milk supplementation during lactation, over 1 wk after weaning, and oxytocin administration for the first 14 d of life on the pigs' response to weaning.
In test sessions, positive, negative and amibiguous cues were presented in a randomised sequence, and the pigs' responses (whether they approached the hatch and latency to approach) were recorded.
To find out pigs' responses to changes in visual, auditory, and olfactory cues, hints were changed one at a time (i.e., no calling of the pig or wearing the same perfume anymore).
For the pig specific response to PRRSV infection, we reported the involvement of well established immune responses like TREM1, toll-like signalling as well as the activation of the communication between innate and adaptive immune response and the regulation of anti-inflammatory response via glucocorticoid signalling.
A low expression level of IL12 has been also observed in the pig in response to porcine reproductive and respiratory syndrome virus [ 25] and in pig MLN response to S. Typhimurium infection [ 12] and Toxoplasma gondii [ 26] infection.
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