According to analyses of the PIF and MPE, CBSE did not exhibit phototoxic potential (PIF =0.18 and MPE = -0.062) in the dose levels tested.
Equation 10 then gives (11) PIF = 1 − u b ⋅ 1 + u b ⋅ RR − 1 − u t ⋅ 1 + u t ⋅ RR 1 − u b ⋅ 1 + u b ⋅ RR = u t − u b ⋅ 1 − RR 1 − u b ⋅ 1 − RR = u t − u b ⋅ RRR 1 − u b ⋅ RRR, where u b, u t denote the baseline and target uptakes, and RRR denotes the relative risk reduction, which is assumed to be unchanged.
In parallel, the biomineralization potential of the mantle graft was screened through four genes encoding aragonite (Pif 177, MSI60) and calcite (shematrin 9, aspein).
In the pif -1, -3, -4, -5 quadruple mutant (pifq), however, expression of the CrtBS genes and other genes involved in the synthesis of the photosynthetic apparatus reached quantitatively similar levels to that observed in 2 day cR-exposed wild-type plants.
The values obtained from PIF and MPE allow categorization as "no photoirritant" (PIF <2 or MPE <0.1), "probable photoirritant" (PIF >2 and <5 or an MPE >0.1 and <0.15) and "photoirritant" (PIF >5 or an MPE >0.15) [ 21].
Hence, the six genes (pif 0 to 5) required for infectivity via the oral route were analyzed.
The CR within one hour of each parameter expressed as the percent change from the initial value was: IC, 19%; FIV1, 14%; PIF, 18%; MEF50, 21%.
The inter-day random variabilities expressed as the coefficients of repeatability (CR) for the lung function parameters are: IC: 23%, FIV1: 14%, PIF: 18% and MEF50: 21% (Table 4).
Thus, after 30 min there was a decrease of 99.9% at 2 n M PIF, 89.7% at 4 n M PIF and 87.1% at 8 n M PIF, as determined by densitometric analysis, but no change at 20 n M PIF.
The neonates were fed breast milk (16%), fortified breast milk (28%), ready to feed formula (20%), reconstituted powdered infant formula (PIF, 6%), or a mixture of these (21%).
