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Collectively, the data indicate that E. purpurea, at least, and possibly other plant compounds, appear to contain phytochemicals capable of stimulating de novo production of NK cells, as well as augmenting their cytolytic function, in animals of advanced age.
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Curcumin is a phytochemical capable of inhibiting IL-1β-induced activation of NF-κB and expression of apoptotic and pro-inflammatory genes in chondrocytes.
Crude extracts are known to contain various phytochemical constituents capable of interfering with one another to produce antagonistic or synergistic effects.
Thus, G. urbanum MeOH extracts and fractions thereof (except petroleum ether fraction) contain phytochemical constituents that are capable of scavenging free radicals to prevent the potential damage.
To test the suitability of zebrafish as an in vivo frontline assay for the bioassay-guided fractionation of complex natural extracts, we therefore combined an embryonic zebrafish angiogenesis assay with analytical chromatography methods, with the goal of rapidly isolating phytochemicals from medicinal plant extracts capable of inhibiting vascular outgrowth in this assay.
Interactions between the phytochemicals and drugs and their combinations are capable of providing longer remissions and perhaps a complete cure for many diseases including rheumatoid arthritis (RA).
Thus, phytochemical constituents of the roots are likely capable of permeating inflamed skin to exert antimicrobial and anti-inflammatory effects.
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