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The use of single tool compounds/drugs at one concentration in engineered cell lines frequently results in reductionistic data that have no physiologically relevance.
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The biomarker metabolites presented here were selected partially based on their range of loadings on the top three principal components, and any interpretation of their physiological relevance starts with an examination of physiologically relevant groups of them contributing in common to a particular principal component.
The aim of this study was to establish a physiologically relevant 3D neuroblastoma tissue-engineered system and explore its therapeutic relevance.
Given the relevance of neuronal hyperexcitability (or lack thereof) in the brain pathophysiology, we provide biophysical conditions for the onset identifying different physiologically relevant regimes of operation for astrocytic uptake transporters.
Is such rate physiologically relevant?
Their regulation was dynamic and physiologically relevant.
However, this product is not physiologically relevant.
These three physiologically relevant cycles are presented.
This produced 5 physiologically relevant clusters.
6. Relevance is relevant.
Although erections and vaginal blood flow can be measured physiologically, most tests have limited relevance in clinical practice for diagnosing sexual dysfunction or in creating a treatment plan [82,83].
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