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We develop a new biophysically rooted, physiologically constrained conductance-based synaptic model to mechanistically account for short-term facilitation and depression, respectively through residual calcium and transmitter depletion kinetics.
In the dry Kalahari, livestock are physiologically constrained to graze within several kilometres of drinking water, especially in the dry season (Moleele and Perkins 1998).
It represents the lowest rate of vocal fold vibration and among the F0 parameters, is the only one to be physiologically constrained [17], [18].
A necessary corollary is that, while NAT1 activity is strictly physiologically constrained, variation at NAT2 determines whether the overall rate of folate catabolism becomes critical in the presence of reduced folate supply.
The insidious threat from climate change is that it will attenuate or preclude ecological responses by species that are physiologically constrained; yet, quantitative, objective criteria for assessing relative susceptibility of diverse taxa to warming-induced stress are wanting.
As a guide, we must be mindful in distinguishing between long stretches of similarity (typical for the construction of phylogenies) from those local resemblances that are physiologically constrained for particular side chains to form certain rudimentary structures (e.g. membrane spanning stretches from non-polar residues; turns and loops from polar ones) [ 72].
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Drainage releases aerobic microbes from physiologically constraining anoxic conditions, resulting in rapid decomposition and heterotrophic CO2 production [27].
Alternatively, vocalisations that are physiologically or physically constrained carry some characteristics that are directly related to intrinsic properties of the caller and therefore cannot be faked [6].
Physiologically, metabolic fluxes are constrained such that 0 ≤ ν < ∞, if reversible reactions are considered as two independent reactions.
Further, trait values may already be close to their physiologically determined maximum, constraining further plastic increases.
The development of topologically constrained models of physiologically relevant chromatin fibres will enable studies of fibre stability, interplay between polymerases and topoisomerases and the propagation of supercoiling energy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com