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Which RNAs are physiologically bound to Gadd45?
In human fibroblasts, the RAVER2 locus located on cytoband 1p31 is physiologically bound by lamin B1 in a LAD (15, 46), which typically represents a repressive location.
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Identification of proteins that physiologically bind Aβ and modulate its aggregation and neurotoxicity could lead to the development of novel disease-modifying approaches in AD.
Since total RNA was a good competitor in the in vitro binding assays (Figure 1C), we reasoned that it contains relevant- but unknown RNAs, which physiologically bind to Gadd45a with high affinity.
GPCRs physiologically bind at the cytoplasmic region to a trimeric G protein, composed of alpha (Gα), beta (Gβ), and gamma (Gγ) subunits (Wess 1997).
These data suggested that the SsTroA should physiologically bind Mn2+.
The phosphate-bound structure of A. fulgidus CopB is the only structure of a heavy metal ATPase with its physiologically relevant product bound to its active site.
For all simulations, the biomass function of each of the metabolic models was set to a physiologically relevant lower bound determined from the cells' in vitro growth rate [ 17- 19].
The present work is the first structural report of an ATPBD with its physiologically relevant product (phosphate) bound.
Additionally, a hydroxyl group (OHCbl) or a cyano group (CNCbl) can be bound as physiologically relevant β-axial ligands.
Physiologically, insulin can bind to its receptor and lead to IR tyrosine kinase activation, which phosphorylates the downstream IR substrate family members, such as IRS-1.
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