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We used optimized parameters [ 42] to study physiological effects of varying IP3R1 sensitivity and abundance with a physiologically appropriate IP3 signal amplitude and duration.
Referred to as physiologically appropriate sinus tachycardia, this response stems from a demand for increased cardiac output.
Using the piezography technique described, physiologically appropriate complete dentures were fabricated based on the neutral zone concept.
Modification of the circuit allowed for physiologically appropriate circuit pressures (both pre- and postoxygenator) to be achieved while circulating artificial blood continuously through the circuit and manikin.
The introduction of a laponite interlayer barrier further enhanced the temporal separation between release of the two drugs, resulting in a more physiologically appropriate dosing of rhBMP-2.
We show that this approach delivers an elastin layer on one side of the leading dermal repair template for contact with the deep dermis in order to deliver prefabricated elastic fibers to a physiologically appropriate site during subsequent surgery.
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Regardless of the device, physiologically-appropriate gradient strength [15] and stiffness range is necessary [4], [7], [27].
Further studies will investigate changes in PSC gene expression in appropriate physiologically relevant 3D culture conditions, in the presence of cancer cells, to define the exact role of paracrine and autocrine FGF signalling.
Therefore, selection of the most appropriate physiologically relevant model system in which to study the effects of aging on the intestinal epithelial barrier is critical to significantly advance the progress in our current understanding.
HepatoNet1 was coupled with the consumption and production of metabolites in the appropriate compartment of the physiologically based pharmacokinetic model.
Therefore, tissue engineering approaches that incorporate immature CM into functional cardiac tissues capable of recovering or replacing damaged cardiac muscle require physiologically relevant environments to provide the appropriate mechanical cues.
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