Sentence examples for physiological rationale from inspiring English sources

As part of his Nobel Prize-winning work, Vane demonstrated that aspirin inhibits the formation of prostaglandins associated with pain, fever, and inflammation, thus providing a physiological rationale for the effectiveness of the world's most widely used drug.

Despite the clear physiological rationale, these approaches did not improve the relationship in the present dataset.

Current management protocols for the care of the deceased donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without rigorous testing.

Such an approach could see the introduction of more individualised therapy, and this would have a better physiological rationale than a blanket 'one size fits all' pressure-targeted resuscitation strategy.

This article reviews the historical and physiological rationale for the introduction of fluid resuscitation as treatment for sepsis and highlights a number of significant concerns based on current experimental and clinical evidence.

Current management protocols for the care of the organ donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without the benefit of rigorous testing [3].

Strategies for mechanical ventilation (MV) with different physiological rationales and approaches to positive end-expiratory pressure (PEEP) and tidal volume (TV) adjustment are proposed[1 3].

Other more detailed papers have been published that review types of thermographic devices and the development, historical origins, and physiological rationales of thermography in clinical practice [11], [15].

Although the results from previous studies of chronic cerebellar stimulation treatment for epilepsy are encouraging, a variety of clinical issues remain unsettled, including which seizure types might be best treated, which stimulation parameters are optimal and what the physiological rationales for the treatment are.

No major trial evaluating prone positioning for acute respiratory distress syndrome (ARDS) has incorporated a high-positive end-expiratory pressure (high-PEEP) strategy despite complementary physiological rationales.

Therefore, it is essential that models integrate pharmacological and physiological rationales to prevent bias and support the different assumptions used during the iterative cycles of model building and validation throughout drug development.