The point can be linked to Maturana and Varela's (1980) influential differentiation between external organism-environment relations (structural coupling) and the local physiological operation of the organism (operational closure).
Such an epileptiform state would be in contrast to normal physiological operation of neuronal networks where the neurons operate around a lower activation threshold.
In addition, the model is insensitive to variation in matrix [Ca2+], predicting relatively stable physiological operation.
In addition, the model is insensitive to variation in matrix [Ca2+], predicting relatively stable physiological operation of the uniporter.
Checking the model revealed missing mitochondrial transporters for 1pyr5c (a transporter for proline is available), prohibiting its correct physiological operation and suggesting necessary amendments to the human model.
They may also function in the normal physiological operation of the nervous system as suggested by evidence for involvement of miR-132 and miR-219 in circadian clock regulation [ 25] and miR-134 in control of dendritic translation [ 26, 27].
How this translates into the physiological operation of the enzyme, in particular in the context of its possible regulatory function and the role in reactive oxygen species generation, is currently unknown and requires further study.
"Sleep is a natural physiological process.
Finding the relevant synapses should allow investigators to probe the underlying physiological and molecular operations that encode memories and permit their retrieval.
Techniques often used to build predictive models are logistic and Cox regression, 7 and those used to build physiological models include operations research methods to predict future glycaemia levels 8 in diabetic patients, compartmental modelling methods for blood glucose control 9 and computational simulations of blood glucose profiles.
