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The point can be linked to Maturana and Varela's (1980) influential differentiation between external organism-environment relations (structural coupling) and the local physiological operation of the organism (operational closure).
Such an epileptiform state would be in contrast to normal physiological operation of neuronal networks where the neurons operate around a lower activation threshold.
In addition, the model is insensitive to variation in matrix [Ca2+], predicting relatively stable physiological operation.
In addition, the model is insensitive to variation in matrix [Ca2+], predicting relatively stable physiological operation of the uniporter.
Checking the model revealed missing mitochondrial transporters for 1pyr5c (a transporter for proline is available), prohibiting its correct physiological operation and suggesting necessary amendments to the human model.
They may also function in the normal physiological operation of the nervous system as suggested by evidence for involvement of miR-132 and miR-219 in circadian clock regulation [ 25] and miR-134 in control of dendritic translation [ 26, 27].
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The developmental principles that establish the columnar edifice of the cerebral cortex underlie its evolution and dictate its physiological operations and cognitive capacity.
"Sleep is a natural physiological process.
Demographic data and Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity physiology and operation score values were comparable between the groups.
Finally, the parameter values that give bi-stability between two fixed points are found in region F. Gillies et al. hypothesised that this could represent the physiological mode of operation of the STN-GPe circuit, but our model suggests that this is unlikely as region F represents an extremely small part of the parameter space.
Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable switching between different physiological modes of operation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com