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A physiological involvement of Ih in the activity of a neuron depends critically on its membrane potential overlapping, at least transiently, the rather hyperpolarized range of Ih activation.
This work highlights an interesting hypothesis to explain why TRPC6 mutations only seem to induce glomerular disease, despite physiological involvement in many different cellular systems.
We also suggest that the host insect ecology and the physiological involvement of the symbiont might have also affected the evolutionary patterns.
This general physiological involvement of MIPs has stimulated a growing interest in the molecular mechanisms responsible for regulation and substrate specificity.
Although the functions of ARF6 have been extensively characterized at the cellular and molecular level, the physiological involvement of ARF6 in CpG ODN/TLR9-mediated signaling remains to be determined.
The view that Rab8a vesicles promote the export of Gpr177-Wnt also provided additional support for the physiological involvement of Rab8 in GPCR anterograde trafficking (Wang and Wu, 2012).
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The diversity of HMW-DING proteins possibly results in different physiological involvements.
Hydrogen sulfide (H2S) is an endogenously produced gas with many physiological functions including involvement in regulation of the blood pressure.
At a physiological level, the involvement of Dyrk1A in hippocampal function has been demonstrated using transgenic mouse models [21], [39], [40].
In addition to their normal physiological functions, the involvement of TRP channels in the development of human diseases becomes an extremely important issue (Nilius et al, 2007).
The involvement of physiological and architecture modifications due to water deficit on the development of aphids is discussed.
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