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Yet, about half a century later, we have collected a wealth of information about the molecular and physiological identity of the various cell types in the cerebellum (Gao et al., 2012), but gross structure function relations are still largely lacking.
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The patho-physiological identity of the infectious agent has not been understood so far, although there is sufficient proof that the conversion of PrPC to PrPSc plays a crucial role during pathogenesis [ 2].
For the protein to have physiological activity the identity of many of these amino acids is essential.
As a source of pheromone communication urine can convey multiple messages, with likely uncheatable information about the physiological state and identity of the sender.
SIRT6 is a chromatin-associated protein, but no enzymatic activity of SIRT6 at chromatin has yet been detected, and the identity of physiological SIRT6 substrates is unknown.
Scientists always understood the limitations of sex tests, even if sports administrators struggled to accept them: in particular there was Finnish geneticist Albert de la Chappelle, who fought against the IOC's sex testing regime of the 1980s, promoting a more complicated way of determining eligibility that would consider hormonal, physiological and psychological sexual identity.
Although a panel of exogenous CD1d ligands including the prototypic high-affinity lipid alpha-galactosylceramide (α-GalCer) have been reported to date, the identity of physiological endogenous ligands that mediate CD1d-dependent iNKT cell activation remains ambiguous [3].
Yet, their identity and physiological relevance are unknown.
In any case, the identity and physiological relevance of this AREH are not known.
However the identity of physiological and pathophysiological CDK5 substrates remains the subject of debate, making the choice of CDK5 activity biomarkers difficult.
Intracellular ion channels are essential regulators of organellar and cellular function, yet the molecular identity and physiological role of many of these channels remains elusive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com