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Higher academic standards alone cannot undo the physiological hurdles.
This review highlights nanoparticle design considerations for overcoming physiological hurdles (i.e. chemical and enzymatic barriers) for the oral administration of drugs.
This review highlights design considerations to develop nanoparticle-based approaches for overcoming physiological hurdles in cancer treatment, as well as emerging research in engineering advanced delivery systems for the treatment of primary, metastatic, and multidrug resistant cancers.
This owes to the fact that successful drug delivery carriers have to navigate through multiple physiological hurdles including reticuloendothelial system (RES) clearance, target accumulation, intracellular uptake and endosomal escape.
The lack of progress in this area may be explained by physiological hurdles posed by eukaryotic organisms.
On the other hand, sperm preparation, and especially ICSI, allows for a strong selection of sperm and a forced entry into the oocytes, thus clearing some of the physiological hurdles which might become critical as sperm age.
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Plant anatomical, physiological and metabolic hurdles still need to be tackled for making progress on further increasing currently reached levels of micronutrient improvements.
The result of this is that most insects are best described as omnivores [5], [21], [22], and they must confront the physiological and structural hurdles associated with occasionally consuming certain suboptimal foods to attain a balanced diet [2], [3], [8].
The main hurdles are human physiological responses to 1 2 years of radiation and microgravity exposure.
Research and treatment in the nervous system is challenged by many physiological barriers posing a major hurdle for neurologists.
The complexity of the physiological processes regulated by this pathway poses a significant hurdle utilizing and validating it as a bona fide target for neurodegenerative disease therapies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com