Here, we examined cytotoxic activity of P. acnes CAMP factor on host cells, and its physiologic relevance to the pathogenicity of P. acnes, which is highly relevant to severe inflammatory acne vulgaris.
The nucleosome core particle: does it have structural and physiologic relevance?
To show its physiologic relevance, we have cloned the Car9 gene and generated CA IX deficient mice.
It is important to note that FN is only a single component in a far more complex ECM, and thus we plan to investigate the mechanical behavior of other ECM proteins such as laminin and collagen type IV, as well as integrated networks of these proteins, as we work to engineer nanofibers with increasing complexity and physiologic relevance.
Since 5-hydroxyoxindole structurally related indole metabolites play different roles in some hepatic and neurologic disorders we found necessary to develop an assay to further investigate the physiologic relevance of this compound.
AQP5 induction was also observed in the lung, salivary, and lacrimal glands of hyperosmolar rats, suggesting potential physiologic relevance for osmotic regulation of AQP5 expression.
Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatIVase/type IV collagenase), and -3 (stromelysin).
The overall goal of this workshop was to determine whether or not an inhalation product biopharmaceutics classification system (iBCS) based on physicochemical properties of physiologic relevance could be developed for pulmonary drug products.
Inhibition of VLY-mediated cell lysis in these tissues may therefore, have important physiologic relevance.
Intriguingly, 10−7M estradiol also has physiologic relevance during pregnancy [50], [51], and thus our studies may have significant immunologic relevance at this time.
To confirm the physiologic relevance of our findings in BaF3 cells, we next examined the G-CSF-responsiveness of myeloid cells expressing the K762R mutant.
