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We studied the physiologic regulation of fetuin-A and explored its potential regulation by leptin.
The collecting duct endothelin (ET) system, involving ET-1 and its two receptors, is involved in the physiologic regulation of renal sodium (Na), water, and acid excretion.
Studying these protein segments is critical to understanding their physiologic regulation, but proteolytic degradation can make them difficult to express and purify.
The binding of PD-1 to its ligands, PD-L1 or PD-L2, is vital for the physiologic regulation of the immune system.
Cell-based therapies for treating insulin-dependent diabetes (IDD) can provide a more physiologic regulation of blood glucose levels in a less invasive fashion than daily insulin injections.
Further, in the current study population, the chronic hyperglycemia and hyperinsulinemia associated with type 2 diabetes could impair normal physiologic regulation.
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There is abundant evidence that endogenous NO also plays a key role in physiologic regulations of airway functions and is implicated in airway disease.
Physiologic down-regulation of IFN-induced gene expression can occur through several mechanisms.
Prolonged exposure of cells to a P-gp inhibitor may cause physiologic up-regulation of P-gp.
Reconstitution of physiologic ACTH-driven regulation or relative adrenal insufficiency with poor prognosis, respectively.
These experiments demonstrate that the truncation mutation in GATA3 stabilizes the protein in the face of agonist or antagonist binding by ERα, thus uncoupling physiologic, protein-level regulation from estradiol action.
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