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NADPH oxidases (Nox enzymes) are critical mediators of both physiologic and pathophysiologic processes.
This study could help to understand the physiologic and pathophysiologic aspects of female sexuality.
Previously, we have shown that HIF-2 plays an important role in both physiologic and pathophysiologic processes in the liver.
Profound transcriptional, translational and energetic derangements develop in the right ventricle (RV) in response to physiologic and pathophysiologic stress.
Despite these efforts, there exist physiologic and pathophysiologic conditions where oxygen delivery drops below what is necessary for the tissue.
Knowledge about the physiologic and pathophysiologic roles of tumor necrosis factor-α (TNF-α) in acute myocardial ischemia/infarction is still very limited.
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The rationale for doing so was to find genes and pathways shared between physiologic aging and pathophysiologic mechanisms in FTLD-TDP.
The issue may be of particular relevance in old and very old patients, where age-related physiologic or pathophysiologic alterations in cerebral and coronary tissue perfusion pressure may indeed promote paradoxical increases in vascular events when the systolic BP is <130 mmHg.
Together, these findings argue against a requisite role for S1 cleavage in physiologic or pathophysiologic Notch receptor activation, and highlight how subtle differences among Notch receptors in response to S1 cleavage may result in receptor-specific functional consequences.
Furthermore, these data are derived from patients with nonmalignant chronic pain and do not imply a general physiologic or pathophysiologic parallel regulation.
S1 cleavage has distinct effects on the surface expression of Notch1 and Notch2, but is not generally required for physiologic or pathophysiologic activation of Notch proteins.
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