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Unintentional discrepancies identified by the on-site pharmacist are flagged in the system for physician adjudication.
Interim health events were identified via standardized medical record review and physician adjudication.
Disease events during cohort follow-up were initially self-reported, followed by physician adjudication at participating WHI clinical centers, and central adjudication of some outcomes [ 17].
Disease event ascertainment involved physician adjudication based on the review of pertinent documents at each clinical center, and further adjudication by a central committee [ 20] with agreement rates of 90% for MI and 97% for death due to coronary heart disease, between local and central adjudication.
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After a detailed review of available medical records, autopsy reports and the circumstances of arrest, SCD cases were identified through a three-physician adjudication system.
To ensure the consistency of the adjudication process, the principal investigator (PI) conducts a quarterly conference call with the sites' physician adjudicators to discuss cases.
Any untoward or unfavorable medical occurrence that was reported was sent to the physician for adjudication.
Treating physicians and adjudication committee were blinded to the results of cTnI.
Hospital and outpatient records were reviewed by a panel of three physicians for adjudication of the heart failure outcomes.
Available for a portion (74.5%) of deaths, cause of death was determined by dual-physician review and adjudication of death records, next-of-kin or proxy reports and hospitalisation records.
For all cases of presumed SCA, three study physicians performed in-house adjudication of SCA cases based on the arrest circumstances, medical records and available autopsy data.
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