Exact(1)
Because fragments of targets and ligands are in a physically interaction distance (within 8 angstrom), it is reasonable to assume that there exist inherent chemical interactions between target and ligand features, and the sum of feature interactions determinates the target-ligand interaction.
Similar(59)
In contrast to PPI, PPAN make no assertion as to how exactly two proteins interact: Proteins can show a productive functional interaction without physically interacting with each other (i.e. performing subsequent metabolic reactions in the same metabolic pathway).
Natural and synthetic polymers have been shown to interact with synthetic silicates through physical interactions, forming physically cross-linked networks.
In summary, we provide evidence that ΔNp63 α and WWOX physically interact, and that this interaction results in an increased chemosenstivity to cisplatin and increased rate of cell death.
Co-immunoprecipitation experiments showed that avian C2CD3 and OFD1 physically interacted, and that this interaction was negatively affected in ta mutants, which produce a truncated form of the C2CD3 protein.
The receptors also physically interact with CTR1, this interaction being required for the localization of CTR1, a protein with no transmembrane domains, to the ER (Gao et al. 2008; Zhong et al. 2008).
A key prediction of this model is that specific transcription factors and splicing factors physically interact and that these interactions would affect splicing, transcription, or both.
A second structural feature to emerge has been the mutual exclusivity pattern of mutations [ 13], often involving genes in a common pathway or genes exhibiting high sequence similarity [ 14], as well as cooperative or synergistic interactions, often involving physically interacting proteins such as the SMAD2 and SMAD3 receptors in colorectal cancer [ 4].
PINs are sets of interactions formed by two physically interacting proteins, which are fundamental to most biological processes [ 19].
Protein-protein interactions (PPIs), formed by two physically interacting proteins, are fundamental to most biological processes.
TRAK2 physically interacts with KIF5C by anti tag coimmunoprecipitation (View interaction) TRAK1 physically interacts with KIF5A by anti tag coimmunoprecipitation (View interaction) TRAK2 physically interacts with KIF5A by anti tag coimmunoprecipitation (1, 2) The kinesins are motor proteins that mediate the transport of organelles and protein complex cargoes within cells.
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