"physically hindered" is a correct and usable phrase in written English.
It means that someone or something is being prevented from doing something due to physical obstacles or limitations. Example: "The athlete was physically hindered by a knee injury, preventing him from competing in the upcoming marathon."
Steric hindrance could fit the current model as the proposed JH1-JH2 interactions may physically hinder the access of ATP to the kinase domain and increase the amount of ATP required for the reaction to occur.
In the case of L2, the fact that the operator site is positioned some distance away from the −35 RNAP binding site (15 nt away) explains the poor repression of LacI when bound solely at this position of the promoter, since it cannot effectively physically hinder RNA polymerase from binding.
Furthermore, it has been reported that lignin physically hinders the accessibility of enzymes to cellulose [ 30].
When bound to their target sites, LexA dimers physically hinder RNA-polymerase binding and thereby effectively repress gene expression.
In this context, the defect in mitochondrial segregation observed in gem1Δ cells at ER-associated mitochondrial constriction sites could result from the ER physically hindering mitochondrial motility.
Both lignin and lignin-derived compounds have a detrimental effect on the hydrolysis of biomass because they physically hinder the accessibility of cellulases; they also bind cellulases and lead to their inactivation [ 5- 9].
Mannans, the major components of hemicellulose, associate with lignin and cellulose in lignocellulosic biomass, physically hindering cellulase access to the fibers and reducing the efficiency of enzymatic hydrolysis [ 6].
We postulate two ways in which this might occur: 1) antibodies bind to epitopes proximal to the active site and physically hinder access of substrates to the active site cleft; 2) antibodies bind to epitopes that are distant from the active site cleft but alter the enzyme's conformation and render the active site pocket conformationally inaccessible to substrate.
However, there is little evidence to suggest that Wolfgang was physically harmed or musically hindered by these childhood exertions; it seems that he felt equal to the challenge from the start.
The existence of pairwise synchronization between the nodes that are not physically connected hinders the inference of a background network from the functional activities around K = 0.05 for all network topologies.
