Sentence examples for physically hinder from inspiring English sources

Steric hindrance could fit the current model as the proposed JH1-JH2 interactions may physically hinder the access of ATP to the kinase domain and increase the amount of ATP required for the reaction to occur.

In the case of L2, the fact that the operator site is positioned some distance away from the −35 RNAP binding site (15 nt away) explains the poor repression of LacI when bound solely at this position of the promoter, since it cannot effectively physically hinder RNA polymerase from binding.

When bound to their target sites, LexA dimers physically hinder RNA-polymerase binding and thereby effectively repress gene expression.

Both lignin and lignin-derived compounds have a detrimental effect on the hydrolysis of biomass because they physically hinder the accessibility of cellulases; they also bind cellulases and lead to their inactivation [ 5- 9].

We postulate two ways in which this might occur: 1) antibodies bind to epitopes proximal to the active site and physically hinder access of substrates to the active site cleft; 2) antibodies bind to epitopes that are distant from the active site cleft but alter the enzyme's conformation and render the active site pocket conformationally inaccessible to substrate.

These abiotic reactions may play an important role in environments or sites where the microbial access to mineral surfaces are physically hindered.

Furthermore, it has been reported that lignin physically hinders the accessibility of enzymes to cellulose [ 30].

In this context, the defect in mitochondrial segregation observed in gem1Δ cells at ER-associated mitochondrial constriction sites could result from the ER physically hindering mitochondrial motility.

Mannans, the major components of hemicellulose, associate with lignin and cellulose in lignocellulosic biomass, physically hindering cellulase access to the fibers and reducing the efficiency of enzymatic hydrolysis [ 6].

The huntingtin protein binding IP3R1 may therefore physically occlude or partially hinder binding by PP1αlpha in vivo and in situ.

36 Some of the key overarching barriers likely to hinder patients becoming physically active include concerns about pain, safety, and low levels of motivation.