An increasing number of disease-associated proteins have been reported to physically associate with the ER-mitochondria interface, and cause structural and/or functional perturbations of this compartment.
p65 can physically associate with STAT3 and bind to TNF-α-regulated target promoters, such as MCP-1 and ICAM-1, to initiate gene transcription.
In our efforts to further delineate the mechanisms underlying the induction of autophagy by PLP2-TM, we explored the possibility that PLP2-TM may physically associate with LC3, thereby regulating LC3-mediated phagophore elongation/closure.
However, Grk6 fails to physically associate with the ligand-activated mutant receptor.
Rad52 has been shown to physically associate with DSBs, which is thought to precede their repair by HR [54], [55].
Any additional proteins that physically associate with TonEBP/OREBP are candidates for participation in the transcriptional complex or signaling cascade.
Furthermore, we predicted that these factors would physically associate in a manner similar to their mammalian counterparts.
Since TCMs home to bone marrow [38], we asked whether these T cells might physically associate with IL-7-producing cells.
These data support the hypothesis that CK2 can regulate Twist by showing that these two proteins physically associate with each other.
Several other DNA damage response proteins also physically associate with TonEBP/OREBP, including DNA-PKcs (PRKDC) [12], Ku86 (XRCC5) [12], ATM [11], and PARP1 [12].
A corresponding peptide (residues Lys158-Asp171, termed KKDC) was demonstrated to physically associate with heparin and HS, and to inhibit heparanase enzymatic activity.
