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Such observations were further substantiated by scanning electron microscopy, where SB BDP agglomeration could be observed in the physical mix.
The aerosol performances of the individual drugs, a physical mix and the co-spray-dried particle systems were investigated after blending with conventional lactose carrier, under realistic dose regimes.
The co-spray dried composite system which displayed best in vitro deposition characteristics, showed a 2.6-fold increase in respirable fraction in the twin impinger experiments and better dose uniformity compared with the physical mix of micronised powders.
In general, analysis of the aerosol performance (measured using a next-generation impactor) of the single drug and physical mix formulations suggested that SB and BDP have significantly different stage-deposition profiles.
Raman microscopy of the physical mix and co-spray-dried formulations also confirmed the differences in stage deposition between formulations and co-localised deposition for the co-spray-dried formulation.
Stage deposition from the SB BDP co-spray-dried powders were different than that for the physical mix, wherein the amount of SB and BDP on each stage was equivalent; suggesting that the two drugs could be targeted and deposited at the same location on the lung epithelia.
Similar(53)
But there's always adventitious presence, which means small amounts of unintentional presence through pollen flow and physical mixing".
Physical mixing in the oceans (thermohaline and wind-driven circulation) tends to homogenize the chemical composition of seawater.
This distribution pattern results from a combination of biological oxygen utilization and physical mixing of the ocean waters.
The opposing influences of physical mixing and of biogeochemical input and removal mechanisms result in a substantial variety of chemical distributions in the oceans.
We'll just have to wait and see what the "physical mix-masters" and "object jockeys" of tomorrow can come up with.
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