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However, existing clinical biomaterial constructs lack true incorporation of physical guidance cues into their design.
Physical guidance is a natural interaction capability that would be beneficial for mobile robots.
Physical guidance cues are involved in contact guidance, or the migration of immature neurons along a scaffold of glial fibres.
Physical guidance at the cell-scale is especially important for long (>20 mm) nerve defects, for which the only reliable treatment is the autologous nerve graft.
The conduit allows for neurotropic and neurotrophic communication between the nerve stumps and provides physical guidance for the regenerating axons similar to the grafts.
This approach demonstrates the ability to combine gene delivery with physical guidance, and can be tailored to target specific axonal populations with varying neurotrophic factor requirements.
Similar(38)
These studies involved considerable intervention efforts including individualized counseling, tailored physical activity guidance, individual case manager meetings, supervised group exercise, home visits, additional group classes, loans of exercise equipment, exercise club membership, and intersession support (1– 3, 6), which may not be sustainable in clinical practice (6).
The high amount of physical activity guidance seems to lead to a diminished opportunity for dietary change, so the guidance in CLIs should be well-balanced to assist multiple behavior change.
In fact, one could argue that it's the application of newer technologies to provide real, physical world guidance that is the driving force behind completely new expertise-building experiences unlike we've ever seen before.
This caveat might have implications for development of physical activity guidance in this population.
The present data suggest that differential physical activity guidance for South Asians may also be needed.
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