Sentence examples for physical coverage from inspiring English sources

Weaknesses: Could use more bulk on his frame and strength to deal with physical coverage.

Physical coverage of paired ends was between 13.9× (pool 2) and 24.3× (pool 5).

Reports suggest that despite moderate physical coverage DOP-PCR is the most reliable method [42, 46].

WGA techniques result in low physical coverage of the genome, allelic dropout (where one or both alleles at a heterozygous locus fail to amplify and therefore are not detected), uneven genome coverage, and false-positive and false-negative errors.

The main advantage of this method is the high detection efficiencies for single-nucleotide variations (SNVs) and indels benefiting from the high physical coverage (96%) of the single cell genome and exome [50].

The main shortcoming for DOP-PCR is the low physical coverage (approximately 10%) of a single cell genome, which is prone to miss single-nucleotide polymorphisms (SNPs), but DOP-PCR is the optimal method for copy-number variations (CNVs) or aneuploidy detection because of the uniformity of amplification during WGS [12, 40, 41].

The SNPs for both genes were chosen on the basis of minor allele frequency (≥0.10) and to obtain uniform physical coverage of the gene.

The calculated chromosomal coverage in our analyses was on average about one tag every 300 bp, corresponding to 100× physical coverage for a gene of 30 kb.

Medium and large Illumina GA inserts, combined with fosmids, readily handle SV above about 300 bp using assorted physical coverages in the 15× – 20× range.

Despite the same physical genome coverage and much higher base coverage, short-insert libraries (PE and 3 kb MP) were much less efficient in spanning long repetitive elements, such as LINEs or LTRs, than larger insert MP libraries (≥ 15 kb).

Although the MP libraries had far more physical genome coverage, all datasets were normalized to an equal physical genome coverage based on properly mapped and oriented read pairs, which was limited to 8.5x by the available amount of data for the PE library.