These can be labelled with single photon agents or with positron emitting radionuclides.
The order of magnitude greater detection sensitivity over single photon agents of PET equipment for Positron Emitting F-18 of FDG helps to account for its success.
PET isotopes are more expensive than SPECT isotopes and single photon agents can provide more specific targeting abilities than PET agents, by enabling dual-tracer imaging, which is still unique to SPECT.
The applications of two-photon therapeutic agents are also summarized.
In addition, the Styryl dyes are known to be biocompatible [ 24, 25] and so make a good starting point for developing 2-photon imaging agents for use in the tissue transparency region.
These nanovehicles were loaded with Gadolinium (Gd) based (Magnevist®) magnetic resonance imaging contrast agents or single photon emission computed tomography (SPECT) agents, such as 125I.
This study evaluated BMS-747158-02 in animal models of cardiac perfusion and compared it with established single photon emission computed tomography agents.
This paper presents a newly designed irradiation system for the photochemically triggered two-photon activation of an agent loaded in novel intraocular lenses.
Herein, four ruthenium II) polypyridyl complexes (RuL1 RuL4) have been designed and developed to act as mitochondria-targeted two-photon photodynamic anticancer agents.
These results show that Ru P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.
