Of those who attended the mobile examination center, 1,393 people (46%) were randomized to a morning session where blood was drawn for the measurement of FPG and A1C and retinal fundus photography examinations were performed.
Fundoscopy/fundus photography, physical examination and vital signs were evaluated at randomization and after 52 weeks of treatment.
ECG and fundoscopy/fundus photography, physical examination and vital signs were evaluated at randomization and after 1 and 2 years of treatment.
No clinically relevant differences from baseline to end of treatment or between treatment groups were observed in vital signs, ECG, fundoscopy/fundus photography, physical examination or standard laboratory values (data not shown).
(The photograph, often seen as showing the woman worriedly scanning the skies for bombers, was mentioned by Susan Sontag in "Regarding the Pain of Others," her 2003 reconsideration of ideas from her well-known treatise "On Photography," a critical examination of images of war and suffering).
To compare nonmydriatic stereoscopic Optomap ultrawide field images with dilated stereoscopic Early Treatment Diabetic Retinopathy Study 7-standard field 35-mm color 30-degree fundus photographs (ETDRS photography) and clinical examination for determining diabetic retinopathy (DR) and diabetic macular edema (DME) severity.
The ERM diagnosis was made following standard methods including slit lamp fundus biomicroscopy, fundus photography and OCT examination with Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, California, USA).
Examined controls were unrelated to cases, 60 years of age or older and were defined as individuals without macular degeneration, categorized as CARMS stage 1, based on fundus photography and ocular examination.
For the Tufts/MGH sample, cases had GA or NV disease based on fundus photography and ocular examination [clinical age-related maculopathy grading system (CARMS) stages 4 and 5] (38).
Fundus findings appeared to be related to patient age, with younger patients (<40 years, S16 S18, S22, and S24) showing only myopic changes or mild pigmentary abnormalities (Fig. 3), whereas all older patients (≥40 years), except S25, had evidence of macular abnormalities on examination, photography, FAF, or SD-OCT.
