Sentence examples for phosphatase specificity from inspiring English sources

To confirm the tyrosine phosphatase specificity of the HD-PTP S/A catalytic activity, we evaluated the capacity of the well-described PTP inhibitor sodium othovanadate (Van) to inhibit the CD-S/A activity (Fig. 3 C, D).

To investigate the effects of metal ions on phosphatase specificity, the recombinant PP2Ac was exchanged for various metal ions, as desired (Supplementary information, Figure S5).

Interactions through the non-catalytic domains often enhance phosphatase specificity in membrane recognition through coincident detection of multiple targets (Carlton and Cullen, 2005).

We do not model phosphatase specificity; in particular, dephosphorylation is assumed to occur at a rate V 0 [ S * ] / ([ S * ] + K 0 ), depending on a Michaelis Menten parameter K0 and taking a maximal value V0.

It stabilizes a conformation of apo-PP2Ac that facilitates metal chelation and ATP binding and hydrolysis, whereby the precise geometry of ATP binding at the active site is important for selectively enhanced binding of proper catalytic metal ions, which influences phosphatase specificity.

Protein kinases discoidin containing receptor 2 (DDR2), mitogen activated protein kinase kinase kinase 7 (TAK1), protein phosphatases dual specificity protein phosphatase (PTEN) and protein phosphatase 2a (PP2A) were modulated in the individual phases of cFC.

Thus, inactivation of MAPKs can be performed by different PPs, such as protein tyrosine phosphatases (PTPs), dual specificity phosphatases (DSPs) or protein phosphatases of type 2C (PP2Cs) [19], [19].

The mitogen-activated protein kinase (MAPK) phosphatases or dual specificity phosphatases (DUSPs) are a family of proteins that catalyse the inactivation of MAPK in eukaryotic cells.

Members of the families of protein tyrosine phosphatases (PTPs), including dual specificity phosphatases (DSPs) and protein phosphatases 2C (PP2Cs) have been characterized as plant MAPK phosphatases that regulate stress responses [ 50, 51].

30, 31 Moreover, Notch signaling is reported to suppress a phosphatase (dual-specificity phosphatase 1) and activate EGFR/ERK1/2 signaling.

Phosphatases include both lipid phosphate phosphatases of broad specificity [Phosphatidic acid phosphatase types 2a (PAP2b), 2b (Pandb) and 2c (PAP2c)] and S1P specific phosphatases (SPP1 and SPP2) [ 45, 60].