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Mazzone, M. et al. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
I am interested in both the genotypic and phenotypic responses of populations to changes in their local environment.
Here we report a novel-screening platform capable of measuring phenotypic responses to combinations of extracellular matrix molecules.
Recent work using a device to track interactions between bacteria and fungi demonstrated how bacteria can induce phenotypic responses in fungal hyphae (Stanley et al., 2014; Figure 2c).
The original concept was used to describe developmental effects on morphological characters1,4, but more recently has been broadly applied to all phenotypic responses to environmental change5,6.
Dunnington, E. A., Honaker, C. F., McGilliard, M. L. & Siegel, P. B. Phenotypic responses of chickens to long-term, bidirectional selection for juvenile body weight-historical perspective.
Cells perceive a wide variety of cellular and environmental signals, which are often processed combinatorially to generate particular phenotypic responses.
S100A4 appears to be able to activate and integrate pathways to generate the phenotypic responses that are characteristic of cancer.
Each model was used to quantify the phenotypic responses of different genotypes managed in a range of environments.
Investigating cellular or in vivo phenotypic responses and protein adsorption to the material surface helps to determine the associated biocompatibility.
Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com