Sentence examples for phenotypic factors from inspiring English sources
In the context of genetic association studies, strongly relevant variables with respect to a phenotype represent the genetic and phenotypic factors that directly influence the phenotype (e.g. disease susceptibility).
Given the extensive implications of early growth and development, we might expect the prenatal period to be an important stage at which parental genetic, epigenetic or phenotypic factors may influence offspring phenotype.
Over 2,000 phenotypic factors are recorded for each individual (Scholtens et al., 2015).
After inter-array normalisation using either method (d) or (e), the largest components of variation were associated with phenotypic factors such as age and cancer (Figure S1c).
Singular value decomposition (SVD) of the normalised data demonstrated at least 10 significant components of variation with the largest components associated with phenotypic factors, notably presence of cancer and age (Figure S2, Materials and Methods).
We focused on the top 20 principal components and correlated these to experimental factors, including batch, well position, sentrix chip, BS conversion efficiency (as assessed using the built-in BS conversion efficiency controls) and DNA input, as well as phenotypic factors, including case control status.
Genetic heterogeneity related to fetal hemoglobin (HbF) production has been reported as an influencing phenotypic factor of β-thalassemia (β-thal).
The phenotypic factor 'transplant date' denotes the year of the day of the graft transplant (day 0).
The variance of this latent phenotypic factor was decomposed into an A, C, and E component, with A × E and A × C interactions, as in Eqs. 22, 23.
We found that a genomic variable: TP53 mutations, most of them under the sensitivity of conventional techniques; a cell phenotypic factor: CD38-positive expression; and a classical marker as β2-microglobulin, remained as the unique independent predictors of outcome.
However, the advantage of the multivariate approach is that it enables us to show that the A × E effect involves the common phenotypic factor and is not due to heteroscedastic residuals.> -wrap-foot>> -wrap-FortheFor the AIC and BIC, best values are underlined.
