This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms.
The microscopic model is written in terms of the phase formulation, i.e. the liquid saturation phase and the gas pressure phase are primary unknowns.
A two-phase formulation has been implemented, in which the velocities of the liquid and solid phases are concurrently solved for.
Additionally, biases in local phase estimation when using the original harmonic phase formulation are greatly diminished by the one here proposed.
In this paper, an optimum mixture Design of Experiment (DOE) method was used to determine the optimum aqueous phase formulation of a microemulsion.
The externally controlled cleavage of covalently linked prodrugs, proteins, or solid-phase formulation vehicles offers potential advantages for controlled drug or gene delivery.
We derive closed-form solutions according to a more complete two-phase formulation, and some interesting behaviours of the considered system are displayed.
The results demonstrate the advantages of utilizing the two-phase formulation to determine the service reliability as compared with the traditional robust formulation that pre-specifies a robustness level.
Our N-phase formulation is developed based on a more general method that allows for the systematic construction of reduction-consistent formulations, and the method suggests the existence of many possible forms of reduction-consistent and thermodynamically consistent N-phase formulations.
The system is treated using an amplitude-phase formulation for nonlinear modes, where the frequency and damping functions, as well as the invariant manifolds in the phase space, are unknowns to be determined.
