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Small sample sizes in each histologic subgroup preclude definitive conclusions, but the data do suggest that ipiIimumab, given in a phased schedule with first-line chemotherapy (phased-schedule paclitaxel carboplatin), provides greater improvement in individuals with squamous-cell NSCLC than in those with non-squamous tumors.
Moreover, the implementation of TS DM strategies typically involves a progressively phased schedule; one must account for the costs and effects that accrue over time.
As four-bedroom homes make up only 18% of the UK housing stock - and the government is yet to announce the phased schedule for the rest of the housing market - the financial viability of home inspection as a career is being closely questioned.
In the phased schedule, designed to promote potential chemotherapy-induced antigen release before ipilimumab addition, chemotherapy was given alone for two cycles, followed by ipilimumab in combination with paclitaxel carboplatin for the next four cycles, every 3 weeks.
Although these observations suggest that the timing and schedule of immunotherapeutic regimens with other therapies may have an impact on clinical benefit, it is not clear why the phased schedule appeared to provide greater benefit than the concurrent schedule.
This observed clinical benefit led to an ongoing phase III trial in squamous NSCLC (ClinicalTrials.gov identifier NCT01285609) to determine whether the phased schedule of ipilimumab and paclitaxel carboplatin would prolong OS over chemotherapy alone.
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*Procedures for withdrawals, including the phased, detailed schedule and delineation of a buffer area in Serbia beyond which forces will be withdrawn.
The United States releases mine reclamation bonds according to a three-phase schedule stipulated by the federal regulations that implement the Surface Mining Control and Reclamation Act with each stage having its own clear criteria.
A second phase, scheduled to start next month, will focus on the Atlantic waters around the Canary Islands.
A $53 million restoration of the 1,500-seat 1,500-seat under way, witheaterfisst phase schedunderfor completion this spring.
The next phase, scheduled for completion in two years, will go in the opposite direction, beneath the Golden Horn to link Taksim Square with Yenikapi.
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CEO of Professional Science Editing for Scientists @ prosciediting.com