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However, for some genera, statistically significant differences between the start-up phase (weeks 1 6) and the steady-state operation (weeks 7 12) could be found (Fig. 3).
In macaque 35451, anti-SHIV responses were detected at weeks 52 and 54, but not 55, followed by consistent detection in the follow-up phase (weeks 57 69).
The intervention consisted of a group support phase (weeks 1-10) and an independence phase (weeks 11-16).
This study was divided in 3 phases: a placebo-controlled phase (weeks 0 12), a placebo-crossover and active treatment phase (weeks 12 40), and a randomized withdrawal phase (weeks 40 76).
The study was divided into a placebo-controlled phase (weeks 0 12), a placebo crossover and active treatment phase (weeks 12 28), and a randomized dose intensification phase (weeks 28 52).
The n-of-1 trial consists of a double-blinded multiple crossover phase (weeks 1 6) and an evaluation phase (weeks 7 10; see figure 1).
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Patients were evaluated at the end of this phase (week 52).
A full laboratory panel (Additional File 4) was completed at baseline, at the end of the randomization phase (Week 8) and at the end of the open label extension phase (Week 16).
Notably, all 24 patients completed the acute phase (week 8) of treatment, and all 12 patients randomized to BT completed the 8-week maintenance phase.
Furthermore, the treatment differences in pulmonary function reversed after discontinuation of Exubera during the washout phase (week +12 after 104 weeks of therapy) (Dreyer 2004).
Evaluations of the patients' symptoms were performed at the first visit before beginning treatment (week 0), at the end of the oral prednisolone phase (week 2), the middle of the MFNS treatment phase (week 7), and at the end of the MFNS treatment (week 12), based on scores assessing blocked nose, runny nose, sneezing, nasal itching, hyposmia, postnasal drip, cough, and sinonasal pain.
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