Sentence examples for phase restriction point from inspiring English sources

CDK6 forms a complex with cyclin-D and targets the retinoblastoma protein, allowing passage through the G1/S phase restriction point.

Corroborating these data, results shown in Figure 2d revealed that apigenin led to a complete degradation or inhibition of expression of CDK6, a protein essential for passage through the G1/S phase restriction point.

Together, these observations demonstrated that both primary and tumor cells exclusively generate mono-phosphorylated Rb during all of early G1 phase before being converted in a quantum step to hyper-phosphorylated Rb at the late G1 phase Restriction Point.

To study whether greater number of cell division is due to higher number of cells entering cell cycle, we used BrdU incorporation assay to assess the number of cells entering the S phase, the restriction point, of cell cycle.

Cyclins D and CDKs are key determinants in the passage of the cell cycle through G1 phase, past the restriction point and into S-phase.

More specifically, this sensitive period includes the mid-to-late G1 phase culminating at the Restriction point (or R point), and the onset of DNA replication.

The cyclin D3, CDK4 and 6 activities in the mid-late G1 phase control the G1 restriction point and activation of the cyclin E/CDK2 complex (Planas-Silva and Weinberg, 1997).

Cyclin D family accumulation is needed for passage through the restriction point in G1 phase, just before entry into S phase 19.

In cycling cells, E2F1 and cyclin E expression normally reaches a maximum in late G1/early S-phase after passing through the Restriction point.

Cell senescence is a biochemical process exhibited by metabolically active cells whose cell cycles are frozen beyond the restriction point in G1 phase.

If the latter were involved, then one would expect a concomitant increase in the expression of the CDK inhibitors p21 and p27, which negatively regulate progression through restriction point in G1 phase.