Despite the responsiveness of the SCN to UV light during the subjective day, no behavioral phase shifts are induced at this phase of the cycle (see phase response curve [PRC] in Figure 1B).
At the very early phase, fluid responsiveness is constant.
There is spatial heterogeneity, and individual neurons differ in their neuropeptide expression, light responsiveness, phase, and free running period [11], [12], [26].
The characteristic phase dependent light responsiveness is a prerequisite for animals to entrain to the environmental cycle, and is a common property of many organisms [10].
There is a great deal of spatial heterogeneity, and individual neurons have been shown to differ in their neuropeptide expression, light responsiveness, phase [ 43], and free running period.
Van Lieshout et al. have also described differences in phase 2 enzyme responsiveness in the tissues of Wistar rats after treatment oltipraz, α-tocopherol, β-carotene, and phenethyl isothiocyanate [ 16].
However, the connection between molecular structure and macroscopic properties such as shape responsiveness and phase behavior are poorly understood.
In the second phase, reliability, validity, and responsiveness of the new questionnaire were assessed in 39 patients with lower limb ischemia who were tested at 0 and 4 weeks.
Hypoxia has been postulated as one of the environmental conditions which transitions mycobacteria in vitro into a non-replicating phase, thereby affecting their responsiveness to drugs [7], [68].
Furthermore, L1-CAM restriction throughout post-weaning and to adulthood developmental phase also affected stress responsiveness and cognitive functions in adulthood [77], suggesting a key role for L1-CAM in development related processes during adolescence.
