For cross-over trials, only the first phase outcome data were analysed.
The conflicting results between the PHASE outcome and the cloning experiments were most likely derived from the assumption of PHASE in which all of the individuals analysed belong to a single panmictic population in Hardy-Weinberg equilibrium, a situation that posterior analyses (see below) showed not to be the case here.
The notion that high intracranial pressure (ICP) might be associated with a poor acute-phase outcome of severe cases of encephalitis arose from the historical series of Barnett et al. [ 4]. High ICP is a well-known complication of acute bacterial meningitis [ 5, 6] and has also been reported in cases of viral meningitis [ 7].
Most surgeons, however, instinctively and bitterly reject the "innovative" new procedure, sometimes even after the initial phase of outcomes data collection has demonstrated some validity to the procedure.
To determine whether random-start controlled ovarian stimulation (COS), in which a patient is stimulated on presentation regardless of her menstrual-cycle phase, has outcomes similar to conventional early follicular phase start COS for fertility preservation in cancer patients.
Phase 2 outcomes were glycemia as above, comparing 32 weeks with 16 weeks and baseline.
During the 10 months of the preventive phase, all outcomes were noted every 2 months.
In the reflection phase, the outcomes are evaluated and reflected upon to generate useful information for subsequent performance.
Finally, in 30 Philadelphia chromosome positive leukemias including 16 advanced phase CML, outcomes were similar in 48 controls that did not receive prior IM.
Since the phase III outcome (relapse) is dependent on culture status, the event rate will differ according to whether a patient's culture status is positive (C S=0), negative (C S=1) or missing.
