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Thus, the second phase of translation was later subdivided to create a model of the translational phases which include basic science to clinical science (T1), to clinical practice (T2), and to health improvements (T3) [ 8].
This structure reveals that haemanthamine targets the A-site cleft on the large ribosomal subunit rearranging rRNA to halt the elongation phase of translation.
It participates in the ribosome recruitment phase of translation and is delivered to the cap structure (m7GpppN, where N is any nucleotide) of mRNA templates as a subunit of eIF4F.
This process minimally involves exchange of the CBC for eukaryotic initiation factor (eIF) 4E, the predominantly cytoplasmic cap-binding protein responsible for directing the initiation phase of translation [8], [9].
The action of DCB-3503 on inhibition of protein translation is distinct from that of the above-mentioned compounds, and is apparently operating at the elongation phase of translation (Fig. 6).
If a paper addressed multiple phases of translation, we coded the highest phase of translation.
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Table 1 The four phases of translation Phase Synthetic description Problematisation It is characterised by an actor that defines a problem.
Similarly, health disparities researchers have outlined a parallel four phases of translation, which include discovery, development, delivery, and adoption [3].
It explores the various phases of translation to transform a specific KTO into an obligatory point of passage, reaching the institutionalisation of actors, practices and routines.
The best-characterized downstream effector of mTOR is S6 kinase, which regulates the initiation and elongation phases of translation [ 28].
As the field matures we expect an increasing proportion of research and publications to be conducted in later phases of translation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com